Reaktion #985261

Reaktionsgleichung

4-nitrobenzoyl chloride

2-aminothiophenol

→

product

Ausbeute 73.2%

2-(4-Nitrophenyl)benzothiazole

Ausbeute 73.2%

Lösungsmittel

benzene

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched with water (20 mL)
2. 2
   SonstigeThe aqueous layer was separated
3. 3
   Extraktionextracted with ethyl acetate (3×10 ml)
4. 4
   SonstigeThe combined organic layers were dried
5. 5
   Sonstigeevaporated
6. 6
   SonstigeThe crude product was purified
7. 7
   Sonstigewith flush column, (hexane:ethyl acetate=85:15)

Vorschrift

A solution of 4-nitrobenzoyl chloride (1.49 g, 8.0 mmol) in benzene anhydrous, 10 mL) was added dropwise to 2-aminothiophenol (1.0 g, 8.0 mmol in 10 ml of benzene) at room temperature. The reaction mixture was allowed to stir for 16 hr. The reaction was quenched with water (20 mL). The aqueous layer was separated and extracted with ethyl acetate (3×10 ml). The combined organic layers were dried and evaporated. The crude product was purified with flush column, (hexane:ethyl acetate=85:15) to give 1.5 g (73.2%) of product as light yellow solid.

Quelle