Reaktion #983900

Reaktionsgleichung

N-[(1R)-1-(4-bromo-2-fluorophenyl)ethyl]-2-methylpropane-2-sulfinamide

HCl dioxane

→

(1R)-1-(4-bromo-2-fluorophenyl)ethanaminium chloride

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   EinengenThe reaction mixture was concentrated in vacuo, and ether
2. 2
   workup.ADDITIONwas added
3. 3
   SonstigeThe white solid was collected
4. 4
   Waschenwashing with cold ether
5. 5
   Sonstigedried under vacuum

Vorschrift

To a solution of N-[(1R)-1-(4-bromo-2-fluorophenyl)ethyl]-2-methylpropane-2-sulfinamide (26.29 g, 81.58 mmol) in 40 mL methanol was added HCl/dioxane (4M, 40.8 mL, 0.163 mol) solution. The reaction mixture was concentrated in vacuo, and ether was added. The white solid was collected, washing with cold ether, and dried under vacuum to yield (1R)-1-(4-bromo-2-fluorophenyl)ethanaminium chloride that gave proton NMR spectra consistent with theory.

Quelle