Reaktion #983167

Reaktionsgleichung

2-Amino-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one

thiophene-2-carboximidothioic acid phenyl ester hydrobromide

→

N-(11-Oxo-10,11-dihydro-5H-dibenzo[b,e][1,4]diazepin-2-yl)-thiophene-2-carboxamidine hydrobromide

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe solvent was evaporated
2. 2
   Sonstigethe residue recrystallized from a mixture of methanol and ether
3. 3
   Sonstigeto give a yellow solid
4. 4
   WaschenThe solid was washed several times with ether (84 mg, 0.20, 84%)

Vorschrift

2-Amino-5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one (Example 6, 54 mg, 0.24 mmol) was dissolved in methanol (10 mL) and thiophene-2-carboximidothioic acid phenyl ester hydrobromide (79 mg, 0.26 mmol) added. The reaction was stirred at room temperature for 4 hr. The solvent was evaporated and the residue recrystallized from a mixture of methanol and ether to give a yellow solid. The solid was washed several times with ether (84 mg, 0.20, 84%).

Quelle