Reaktion #9829

Reaktionsgleichung

3-(2-bromo-6-fluorophenyl)-3,4-dihydro-7-methanesulphonyl-1-methyl-pyrimido[4,5-d]pyrimidin-2(1H)-one

7-Amino-4-methyl-4H-benzo[1,4]thiazin-1,1-dioxide

material n

7-Amino-4-methyl-4H-benzo[1,4]thiazin-1,1-dioxide

HCl

→

title compound

Ausbeute 31.1%

3-(2-bromo-6-fluoro-phenyl)-1-methyl-7-(4-methyl-1,1-dioxo-1,2,3,4-tetrahydro-1lambda*6*-benzo[1,4]thiazin-7-ylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Ausbeute 31.1%

Lösungsmittel

NMP

ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe mixture was purified by preparative HPLC-MS

Vorschrift

83 mg 3-(2-bromo-6-fluorophenyl)-3,4-dihydro-7-methanesulphonyl-1-methyl-pyrimido[4,5-d]pyrimidin-2(1H)-one and 85 mg 7-Amino-4-methyl-4H-benzo[1,4]thiazin-1,1-dioxide (starting material n)) in 0.8 ml NMP were treated with 0.2 ml 2M HCl in ether and heated to 120° C. for 6 hrs. The mixture was purified by preparative HPLC-MS to yield 34 mg of the title compound.

Quelle