Reaktion #9828

Reaktionsgleichung

compound

3-(2-bromo-phenyl)-1-methyl-7-(4-methyl-3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-7-ylamino)-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

oxone

MeOH

→

title compound

3-(2-Bromo-phenyl)-7-(3-methoxy-4-methyl-1-oxo-1,4-dihydro-1lambda*4*-benzo[1,4]thiazin-7-ylamino)-1-methyl-3,4-dihydro-1H-pyrimido[4,5-d]pyrimidin-2-one

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was filtered
2. 2
   Waschenthe residue washed with THF
3. 3
   EinengenThe combined filtrates were concentrated
4. 4
   Sonstigepurified by preparative HPLC-MS

Vorschrift

100 mg of the compound from example 9 and 108 mg oxone were stirred in 2 ml MeOH at room temperature for 17 hrs. The mixture was filtered and the residue washed with THF. The combined filtrates were concentrated and purified by preparative HPLC-MS to yield 10 mg of the title compound.

Quelle