Reaktion #9815

Reaktionsgleichung

6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

hydrogen

→

title compound

Ausbeute 46.4%

6-Amino-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide

Ausbeute 46.4%

Lösungsmittel

THF

MeOH

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was filtered off
2. 2
   Sonstigethe filtrate evaporated
3. 3
   Sonstigethe residue chromatographed on silica

Vorschrift

0.917 g 6-Nitro-2,3-dihydro-benzo[1,4]oxathiine-4,4-dioxide (from g)) were hydrogenated in a mixture of 20 ml THF and 20 ml MeOH with 0.90 g 5% Pd—C at atmospheric hydrogen pressure for 90 min. at room temperature. The catalyst was filtered off, the filtrate evaporated and the residue chromatographed on silica to yield 370 mg of the title compound.

Quelle