Reaktion #981390

Reaktionsgleichung

ester

Methyl 6,11-Dihydro-11-methoxydibenz[b,e]oxepin-2-carboxylate

sodium hydroxide

→

title product

6,11-dihydro-11-methoxydibenz[b,e]oxepin-2-carboxylic Acid

Lösungsmittel

water

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturreflux for 10 minutes
2. 2
   Extraktionextract with ether
3. 3
   Extraktionextract into ether
4. 4
   SonstigeEvaporate to dryness
5. 5
   Sonstigecrystallize from methanol

Vorschrift

Dissolve 695 mg of the ester of Step A in 15 ml of methanol. Add 10 ml of 20% aqueous sodium hydroxide and reflux for 10 minutes. Dilute with 200 ml of water and extract with ether. Acidify the aqueous fraction with concentrated hydrochloric acid and extract into ether. Evaporate to dryness and crystallize from methanol to obtain the title product (m.p. 185° C. dec.).

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