Reaktion #981385

ord-f95130f624694dc18cad3d9e7606e10a

Reaktionsgleichung

COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
ester
COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
Methyl 6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylate
[Na+].[OH-]
sodium hydroxide
Cl
hydrochloric acid
→
CS(=O)(=O)C1c2ccccc2COc2ccc(C(=O)O)cc21
title product
CS(=O)(=O)C1c2ccccc2COc2ccc(C(=O)O)cc21
6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylic Acid

Edukte

COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
ester
COC(=O)c1ccc2c(c1)C(S(C)(=O)=O)c1ccccc1CO2
Methyl 6,11-Dihydro-11-methylsulfonyldibenz[b,e]oxepin-2-carboxylate
[Na+].[OH-]
sodium hydroxide
Cl
hydrochloric acid

Reagenzien

Keine

Lösungsmittel

O
water

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturReflux 1 gm
  2. 2
    SonstigeSeparate the solids
  3. 3
    Filtrationby filtration

Vorschrift

Reflux 1 gm. of the ester of Step A and 40 cc. of 1 N aqueous sodium hydroxide for 15 minutes. Strip to dryness and dissolve the residue in water. Acidify with aqueous hydrochloric acid. Separate the solids by filtration to obtain the title product (m.p. 251° C. dec.).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04282365uspto-grants-1981_08