Reaktion #981383

ord-51e939ef08144fca9efef3a01791fcd8

Reaktionsgleichung

O=S(Cl)Cl
thionylchloride
COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate
O=S(Cl)Cl
thionyl chloride
→
O=S(Cl)Cl
thionyl chloride
COC(=O)c1ccc2c(c1)C(Cl)c1ccccc1CO2
title product
Ausbeute 100.0%
COC(=O)c1ccc2c(c1)C(Cl)c1ccccc1CO2
Methyl 6,11-Dihydro-11-chlorodibenz[b,e]oxepin-2-carboxylate
Ausbeute 100.0%

Edukte

O=S(Cl)Cl
thionylchloride
COC(=O)c1ccc2c(c1)C(O)c1ccccc1CO2
methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate
O=S(Cl)Cl
thionyl chloride

Reagenzien

Keine

Lösungsmittel

c1ccccc1
benzene

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    TemperaturReflux 3.14 gm

Vorschrift

Reflux 3.14 gm. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate and 15 cc. of thionyl chloride for 10 minutes. Evaporate excess thionylchloride. Remove traces of thionyl chloride by co-distillation with benzene to obtain the title product (yield 3.35 gm., 100%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04282365uspto-grants-1981_08