Reaktion #981382

Reaktionsgleichung

methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate

tetrahydrofuran

sodium hydroxide

→

title product

6,11-Dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylic Acid

Lösungsmittel

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.DISSOLUTIONDissolve 900 mg
2. 2
   workup.ADDITIONAdd 20 cc
3. 3
   Extraktionextract with ether
4. 4
   Extraktionextract with ether
5. 5
   SonstigeEvaporate the organic phase

Vorschrift

Dissolve 900 mg. of methyl 6,11-dihydro-11-hydroxydibenz[b,e]oxepin-2-carboxylate in 20 cc. of tetrahydrofuran. Add 20 cc. 1 N aqueous sodium hydroxide. Stir at room temperature for 48 hours. Dilute with water and extract with ether. Acidify the aqueous fraction with hydrochloric acid and extract with ether. Evaporate the organic phase to obtain the title product (m.p. 275° C. dec.).

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