Reaktion #9812

Reaktionsgleichung

HCl

pyridinium bromide

10-methoxy-5H-dibenz[b,f]azepine

NaOCN

→

oxcarbazepine

Ausbeute 58.0%

Lösungsmittel

toluene

water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe carbamoylation reaction
2. 2
   Temperaturthe mixture was heated to 55–60° C.
3. 3
   TemperaturThe reaction mixture was warmed
4. 4
   Sonstigepurified as in Example 1

Vorschrift

The carbamoylation reaction was performed as in Example 1. After about 7–8 hours of stirring the carbamoylation reaction mixture (containing pyridinium bromide, 10-methoxy-5H-dibenz[b,f]azepine, water, toluene, and NaOCN) at room temperature (22° C.), the mixture was heated to 55–60° C., and 500 ml of 10% HCl was added drop-wise and carefully. The reaction mixture was warmed to reflux (89° C.) for 3–4 hours, and then worked up and purified as in Example 1. 32.8 g (58% yield) of crude oxcarbazepine was obtained. The crude afforded 24.9 g (44% overall yield) of pure oxcarbazepine.

Quelle