Reaktion #980640

Reaktionsgleichung

compound

Methyl-3,4-dihydro-7-[3-[3-hydroxy-2-(2-propenyl)-4-(1-pyrrolidinylcarbonyl)phenoxy]propoxy]-2-propyl-2H-1-benzopyran-2-carboxylate

dimethyl sulfate

potassium hydroxide

→

crude material

Methyl 3,4-dihydro-7-[3-[3-methoxy-2-(2-propenyl) 4-(1-pyrrolidinylcarbonyl)phenoxy]propoxy]-2H-1-benzopyran-2-carboxylate

Lösungsmittel

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   WaschenThe reaction mixture was washed with water
2. 2
   Extraktionthoroughly extracted with ethyl acetate
3. 3
   TrocknenThe organic layer was dried over magnesium sulfate
4. 4
   Einengenconcentrated in vacuo

Vorschrift

The compound of Example 27 (280 mg, 0.51 mmol) dimethyl sulfate (192 mg, 153 mmol) and potassium hydroxide (57 mg, 1 mmol) was added to about 20 ml of THF, and the reaction mixture was stirred overnight at room temperature. The reaction mixture was washed with water and thoroughly extracted with ethyl acetate. The organic layer was dried over magnesium sulfate and concentrated in vacuo. Chromatography of the crude material on silica gel using 75% ethyl acetate/hexane as eluant gave the product.

Quelle