Reaktion #980253

Reaktionsgleichung

1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene

hydrazinecarbothioic acid O-methylester

→

5-[2-(4-acetamidophenyl)ethanyl]-5,6-dihydro-1,3,4-thiadiazin-2(3H)one

Lösungsmittel

toluene

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwas refluxed for 3 h
2. 2
   FiltrationThe crystals were filtered
3. 3
   Waschenwashed with toluene

Vorschrift

A mixture containing 4.0 g of 1-chloro-4-(4-acetamidophenyl)-2-oxo-3-butene (J. Org. Chem., 28, 2446, 1963) and 2.3 g of hydrazinecarbothioic acid O-methylester in 150 ml of toluene was refluxed for 3 h. The crystals were filtered and washed with toluene. Yield 3.0 g (65%), mp. 235°-240° C.

Quelle