Reaktion #979454

Reaktionsgleichung

compound 2

4-[(2-Methoxy-benzoylamino)-methyl]-4-thiophen-2-yl-piperidine-1-carboxylic acid ethyl ester

triethylamine

o-anisoyl chloride

tetrahydrofuran

tetrahydrofuran

→

compound

4-(2-Methoxy-benzoylamino)-4-phenyl-piperidine-1-carboxylic acid benzyl ester

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas removed by evaporation
2. 2
   Sonstigethe residue was purified by prep LC

Vorschrift

A solution of compound 2 (0.03 g; 0.009 mmol) in tetrahydrofuran (2 mL) was treated with triethylamine (0.1 mL; 0.7 mmol) and o-anisoyl chloride (0.05 g; 0.3 mmol) at room temperature. After stirring 15 h the tetrahydrofuran was removed by evaporation and the residue was purified by prep LC to give 0.011 g of compound 4-(2-methoxy-benzoylamino)-4-phenyl-piperidine-1-carboxylic acid benzyl ester as a white solid. LCMS m/z=461 (M+H)+.

Quelle