Reaktion #979433

Reaktionsgleichung

1,3-dimethyl-pyrimidine-2,4,6-trione

1-[2-(4-allyloxy-phenylmethanesulfinyl)-ethyl]-1H-[1,2,3]triazole

→

4-(2[1,2,3] triazol-1-yl-ethanesulfinylmethyl)-phenol

Ausbeute 83.0%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturto cool down over night
2. 2
   ExtraktionThe reaction mixture was extracted with three portions of sodium bicarbonate solution
3. 3
   Extraktionextracted three times with ethyl acetate
4. 4
   ExtraktionThe organic extract
5. 5
   Sonstigewas dried
6. 6
   Sonstigeevaporated

Vorschrift

To a solution of 28.46 g (0.182 mol) 1,3-dimethyl-pyrimidine-2,4,6-trione and 1.81 g (1.57 mmol) tetrakis-(triphenylphosphine)-palladium in 600 ml dichloromethane was added dropwise a solution of 17.70 g (60.75 mmol) 1-[2-(4-allyloxy-phenylmethanesulfinyl)-ethyl]-1H-[1,2,3]triazole and stirring was continued for 6 hours at 45° C. It was allowed to cool down over night. The reaction mixture was extracted with three portions of sodium bicarbonate solution, then the aqueous phase was adjusted to pH 1 and extracted three times with ethyl acetate. The organic extract was dried and evaporated to yield 12.6 g (83%) 4-(2[1,2,3] triazol-1-yl-ethanesulfinylmethyl)-phenol as white solid.

Quelle