Reaktion #979301

Reaktionsgleichung

water

sodium azide

ammonium chloride

Compound 75

(R)-8-Benzyl-5-cyano-2-cyclopentyl-7,8-dihydro-1H-imidazo[2,1-i]purine

→

title compound

Ausbeute 83.0%

(R)-8-Benzyl-2-cyclopentyl-7,8-dihydro-5-(1H-tetrazol-5-yl)-1H-imidazo[2,1-i]purine

Ausbeute 83.0%

Lösungsmittel

1-methyl-2-pyrrolidinone

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe deposited crystals were collected by filtration

Vorschrift

Compound 75 (69 mg, 0.200 mmol) obtained in Example 75 was dissolved in 1-methyl-2-pyrrolidinone (1 mL), to the solution were added sodium azide (52 mg, 0.800 mmol, 4.0 equivalents) and ammonium chloride (42 mg, 0.800 mmol, 4.0 equivalents), and the mixture was stirred at 120° C. for 2 hours. To the reaction mixture was added water, and the deposited crystals were collected by filtration to obtain the title compound (64 mg, 83%) as a white solid.

Quelle