Reaktion #979300

Reaktionsgleichung

water

cesium carbonate

potassium cyanide

Compound 67a

(R)-8-benzyl-5-chloro-2-cyclopentyl-7,8-dihydro-1H-imidazo[2,1-i]purine

→

title compound

Ausbeute 73.0%

(R)-8-Benzyl-5-cyano-2-cyclopentyl-7,8-dihydro-1H-imidazo[2,1-i]purine

Ausbeute 73.0%

Lösungsmittel

N,N-dimethylformamide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Filtrationthe deposited crystals were collected by filtration

Vorschrift

Compound 67a (217 mg, 0.529 mmol) obtained in Example 67 was dissolved in N,N-dimethylformamide (4 mL), to the solution were added cesium carbonate (245 mg, 0.750 mmol, 1.5 equivalents) and potassium cyanide (39 mg, 0.600 mmol, 1.2 equivalents), and the mixture was stirred at 100° C. for 4 hours. To the reaction mixture was added water, and the deposited crystals were collected by filtration to obtain the title compound (125 mg, 73%) as a yellow solid.

Quelle