Reaktion #9790

ord-7a45ae9fe9034a5182d6f166a7d872ad

Reaktionsgleichung

CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
ethyl[4-(bromosulfonyl)-2-chlorophenoxy]acetate
CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
intermediate 114
CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
ethyl[4-(bromosulfonyl)-2-chlorophenoxy]acetate
CCc1cc(SCc2cc(-c3ccc(C(F)(F)F)cc3)oc2C)ccc1OCC(=O)O
{2-ethyl4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid
CCc1cc(SCc2cc(-c3ccc(C(F)(F)F)cc3)oc2C)ccc1OCC(=O)O
{2-ethyl-4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid
→
Cc1oc(-c2ccc(C(F)(F)F)cc2)cc1CSc1ccc(OCC(=O)O)c(Br)c1
title compound
Cc1oc(-c2ccc(C(F)(F)F)cc2)cc1CSc1ccc(OCC(=O)O)c(Br)c1
{2-bromo-4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid

Edukte

CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
ethyl[4-(bromosulfonyl)-2-chlorophenoxy]acetate
CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
intermediate 114
CCOC(=O)COc1ccc(S(=O)(=O)Br)cc1Cl
ethyl[4-(bromosulfonyl)-2-chlorophenoxy]acetate
CCc1cc(SCc2cc(-c3ccc(C(F)(F)F)cc3)oc2C)ccc1OCC(=O)O
{2-ethyl4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid
CCc1cc(SCc2cc(-c3ccc(C(F)(F)F)cc3)oc2C)ccc1OCC(=O)O
{2-ethyl-4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

The title compound was prepared from ethyl[4-(bromosulfonyl)-2-chlorophenoxy]acetate (intermediate 114) by a method analogous to that used for the preparation of {2-ethyl4-[({2-methyl-5-[4-(trifluoromethyl)phenyl]-3-furyl}methyl)thio]phenoxy}acetic acid (example 145).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07091237B2uspto-grants-2006_08