Reaktion #978102

Reaktionsgleichung

4-iodobenzoic acid

pentafluorophenol

diisopropylcarbodiimide

glucosamine hydrochloride

NEt3

→

4-iodobenzoyl glucosamine

Lösungsmittel

DMF

DMF H2O

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.STIRRINGThe reaction was stirred for 16 hours
2. 2
   Sonstigecrystallized from hot water

Vorschrift

To a solution of 4-iodobenzoic acid (1 mmol) in DMF (2 mL) was added pentafluorophenol (2 mmol) and diisopropylcarbodiimide (1.2 mmol). The solution was stirred at room temperature for 6 hours and then added to a solution of glucosamine hydrochloride (1 mmol) and NEt3 (2 mmol) in DMF/H2O (1 mL, 1:10 v/v). The reaction was stirred for 16 hours and then crystallized from hot water to yield 4-iodobenzoyl glucosamine, compound TP010. The structure of TP010 is shown below (R is I).

Quelle