Reaktion #9756

Reaktionsgleichung

hydrochloric acid

1-(5-bromo-3-methylthien-2-yl)ethanone

intermediate 82

1-(5-bromo-3-methylthien-2-yl)ethanone

sodium borohydride

→

title compound

(5-bromo-3-methylthien-2-yl)methanol

Lösungsmittel

ethanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturwarmed to room temp for 30 minutes
2. 2
   Extraktionthe reaction mixture was extracted with ethyl acetate twice
3. 3
   Trocknendried with brine and over magnesium sulfate

Vorschrift

A mixture of 1-(5-bromo-3-methylthien-2-yl)ethanone (intermediate 82, 5.13 g) in ethanol (50 ml) was treated with sodium borohydride (0.947 g). The reaction was stirred at 0° C. for 60 minutes and warmed to room temp for 30 minutes. 2M Aqueous hydrochloric acid was added and the reaction mixture was extracted with ethyl acetate twice. The organic solutions were combined and dried with brine and over magnesium sulfate. The title compound was isolated after removal of the desiccant and evaporation of the solvent.

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