Reaktion #975232

Reaktionsgleichung

4-(chloromethyl)benzoic acid

ethyl 3-aminopropionate

→

compound 13f

Ethyl 3-(4-(chloromethyl)benzamido)propanoate

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeEthyl 3-(4-(chloromethyl)benzamido)propanoate 13f was prepared

Vorschrift

Ethyl 3-(4-(chloromethyl)benzamido)propanoate 13f was prepared by coupling 4-(chloromethyl)benzoic acid 24 with ethyl 3-aminopropionate 25 according to the procedure described for the compound 13e in Example 21 (Scheme 8). The compound 13f was isolated as colorless oil in 84% yield (2.26 g). 1H NMR (400 MHz, CDCl3): δ 1.26 (3H, t, J=7.2 Hz); 2.64 (2H, m); 3.72 (2H, m); 4.14 (2H, q, J=7.2 Hz); 4.61 (2H, s); 6.89 (1H, broad s); 7.53 (1H, s); 7.67 (1H, s); 7.70 (1H, s). 7.80 (1H s). MS (ESI): m/z=270.00 (M+H+).

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