Reaktion #9750

Reaktionsgleichung

water

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

intermediate 69

ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate

bromine

→

title compound

ethyl{4-[2-(5-bromothien-2-yl)ethoxy]-2-methylphenoxy}acetate

Lösungsmittel

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe resulting suspension extracted with diethyl ether
2. 2
   SonstigeThe organic layer was separated
3. 3
   Trocknendried over sodium sulfate
4. 4
   Einengenconcentrated

Vorschrift

A solution of ethyl[2-methyl-4-(2-thien-2-ylethoxy)phenoxy]acetate (intermediate 69, 0.306 g) in acetic acid (5 ml) was treated with bromine (0.180 g) at ambient temperature and the mixture stirred for 15 minutes. The mixture was poured into water and the resulting suspension extracted with diethyl ether. The organic layer was separated, dried over sodium sulfate and concentrated to give the title compound as a colourless oil.

Quelle