Reaktion #974249

ord-e9b8cb5067624e4584fe6cf59f0f4fad

Reaktionsgleichung

COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1
23c
COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1
4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate
Cl
compound 24a
Cl
hydrochloride
→
COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1.Cl
hydrochloride salt
COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1.Cl
4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride

Edukte

COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1
23c
COc1ccccc1N1CCN(CCCCOC(=O)c2ccc3c(c2)NC(=O)CC3)CC1
4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate
Cl
compound 24a
Cl
hydrochloride

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Vorschrift

4-(4-(2-Methoxyphenyl)piperazin-1-yl)butyl 2-oxo-1,2,3,4-tetrahydroquinoline-7-carboxylate hydrochloride (24c) (Scheme 4) was prepared from 23c according to the protocol described for the compound 24a (Example 39). The hydrochloride salt 24c gave satisfactory 1H NMR spectral data. Off-white solid, 0.04 g (43%). MS (ESI): m/z=438.2 (M+H+).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08247420B2uspto-grants-2012_08