Reaktion #974130

Reaktionsgleichung

tert-butyl 9-(tetrahydrofuran-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

hydrogen chloride-ethyl acetate

→

desired product

Ausbeute 92.8%

9-(tetrahydrofuran-3-yl)-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

Ausbeute 92.8%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated under reduced pressure
2. 2
   SonstigeThe residue was recrystallized from a mixed solvent of methanol and ether

Vorschrift

A mixture of tert-butyl 9-(tetrahydrofuran-3-yl)-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (430 mg, 1.35 mmol), ethyl acetate (2 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred at room temperature for 1 hr, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (320 mg, 92.8%) as a solid.

Quelle