Reaktion #974091

Reaktionsgleichung

tert-butyl 9-cyclohexyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate

hydrogen chloride-ethyl acetate

→

desired product

Ausbeute 92.6%

9-cyclohexyl-2,3,4,5-tetrahydro-1,4-benzoxazepine hydrochloride

Ausbeute 92.6%

Lösungsmittel

ethyl acetate

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe solvent was evaporated under reduced pressure
2. 2
   SonstigeThe residue was recrystallized from a mixed solvent of methanol and ether

Vorschrift

A mixture of tert-butyl 9-cyclohexyl-2,3-dihydro-1,4-benzoxazepine-4(5H)-carboxylate (150 mg, 0.453 mmol), ethyl acetate (1 ml) and 4N hydrogen chloride-ethyl acetate solution (4 ml) was stirred for 1 hr at room temperature, and the solvent was evaporated under reduced pressure. The residue was recrystallized from a mixed solvent of methanol and ether to give the desired product (112 mg, 92.6%) as a solid.

Quelle