Reaktion #9733

Reaktionsgleichung

4′-(trifluoromethyl)acetophenone

N-(1,1-dimethoxyethyl)-N,N-dimethylamine

→

title compound

3-(dimethylamino)-1-[4-(trifluoromethyl)phenyl]but-2-en-1-one

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   TemperaturThe reaction mixture was cooled
2. 2
   Einengenconcentrated
3. 3
   Sonstigegiving an orange solid

Vorschrift

A mixture of 4′-(trifluoromethyl)acetophenone (9.8 g) and N-(1,1-dimethoxyethyl)-N,N-dimethylamine (8.2 g) was heated at 112° C. overnight, under nitrogen. The reaction mixture was cooled and concentrated giving an orange solid. Trituration with diethyl ether gave the title compound as a yellow solid

Quelle