Reaktion #972831

Reaktionsgleichung

2-amino-5-bromo-N,3-dimethylbenzamide

1-methylnaphthalene

sodium cyanide

1-butyl-1H-imidazole

→

title compound

2-amino-5-cyano-N,3-dimethylbenzamide

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeA 100-mL, three-necked flask equipped with a mechanical stirrer
2. 2
   Temperaturwhile maintaining a flow of nitrogen through a gas inlet line
3. 3
   TemperaturThe mixture was heated to between 158 and 167° C. for 5 h
4. 4
   Temperaturto cool overnight
5. 5
   workup.STIRRINGwhile stirring
6. 6
   workup.STIRRINGAfter stirring for an additional 1 h
7. 7
   Filtrationthe reaction mixture was filtered
8. 8
   Sonstigethe solid collected
9. 9
   Waschenwas washed water (3×10 mL), xylenes (10 mL)
10. 10
    Sonstigedried to a constant weight in a vacuum-oven at 80° C.

Vorschrift

A 100-mL, three-necked flask equipped with a mechanical stirrer, thermometer and condenser was charged with 2-amino-5-bromo-N,3-dimethylbenzamide (prepared by the method of Reference Example 1) (99.1% purity, 5.0 g, 0.02 mol) and 1-methylnaphthalene (20 g) while maintaining a flow of nitrogen through a gas inlet line connected to the condenser. The reaction mixture was stirred at room temperature, and sodium cyanide (ground to a powder just prior to use) (1.25 g, 0.024 mol, assuming 95% purity), copper(I) iodide (0.57 g, 0.003 mol, 98% purity) and 1-butyl-1H-imidazole (2.15 g, 0.017 mol, 98% purity) were added. The mixture was heated to between 158 and 167° C. for 5 h and then allowed to cool overnight. Water (20 mL) was added dropwise to the reaction mixture over 5 minutes while stirring. After stirring for an additional 1 h, the reaction mixture was filtered, and the solid collected was washed water (3×10 mL), xylenes (10 mL) and dried to a constant weight in a vacuum-oven at 80° C. to give the title compound as a light brown solid (3.4 g).

Quelle