Reaktion #972717

Reaktionsgleichung

Intermediate 20

Ethyl (2E)-4,4-difluoro-4-phenylbut-2-enoate

→

Ethyl 4,4-difluoro-4-phenylbutanoate

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe mixture was then filtered over Celite
2. 2
   Sonstigethe solvent removed under reduced pressure
3. 3
   SonstigeThe residue (0.91 g) was used in the next step without further purification

Vorschrift

A solution of Intermediate 20 (1 g, 4.42 mmol) in methanol (20 mL) was hydrogenated in the presence of palladium on charcoal (10 mg, 10%) for 3 hours. The mixture was then filtered over Celite and the solvent removed under reduced pressure. The residue (0.91 g) was used in the next step without further purification.

Quelle