Reaktion #972274

Reaktionsgleichung

4,4′-dihydroxystilbene

→

4-[4-Hydroxy-phenethyl]-phenol

Ausbeute 97.1%

Lösungsmittel

MeOH

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe catalyst was removed by filtration
2. 2
   Einengenthe filtrate was concentrated
3. 3
   SonstigeChromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1)

Vorschrift

A solution of 4,4′-dihydroxystilbene (250 mg, 1.178 mmol) in MeOH (10 mL) and EtOAc (2 mL) containing 5% Pd—C (120 mg) was stirred under an atmosphere of hydrogen for 2 h. The catalyst was removed by filtration and the filtrate was concentrated. Chromatography purification of the crude product on silica gel (hexane-EtOAc 3:1, 2:1) provided 245 mg of 4-[4-Hydroxy-phenethyl]-phenol (97%) as a white solid. MS (ES) m/z: 213.05 (M−1).

Quelle