Reaktion #972101

Reaktionsgleichung

4-propylphenol

nitric acid

→

4-propyl-2-nitrophenol

Ausbeute 100.0%

Lösungsmittel

acetic acid

acetic acid

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added dropwise with the temperature
2. 2
   Sonstigekept at 10-15° C.
3. 3
   Extraktionextracted with ethyl acetate
4. 4
   WaschenThe combined organic layers were washed with water
5. 5
   Trocknena saturated aqueous solution of sodium hydrogencarbonate and a saturated sodium chloride solution, dried over magnesium sulfate
6. 6
   Einengenconcentrated under reduced pressure

Vorschrift

To a mixture of 5.0 g of 4-propylphenol and 35 ml of acetic acid, a mixture of 3.80 g of 61% nitric acid and 10 ml of acetic acid was added dropwise with the temperature kept at 10-15° C., which was stirred for four hours. The reaction mixture was poured into ice water and extracted with ethyl acetate, The combined organic layers were washed with water, a saturated aqueous solution of sodium hydrogencarbonate and a saturated sodium chloride solution, dried over magnesium sulfate, and then concentrated under reduced pressure to give 6.65 g of 4-propyl-2-nitrophenol.

Quelle