Reaktion #9720

Reaktionsgleichung

1-(4-Hydroxy-3-methylphenyl)ethanone

cesium carbonate

ethyl bromoacetate

cesium carbonate

Ethyl bromoacetate

→

title compound

ethyl(4-acetyl-2-methylphenoxy)acetate

Lösungsmittel

acetonitrile

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheating
2. 2
   workup.WAITcontinued for a further hour
3. 3
   SonstigeThe cooled reaction
4. 4
   Filtrationwas filtered
5. 5
   Einengenthe filtrate concentrated

Vorschrift

1-(4-Hydroxy-3-methylphenyl)ethanone (90 g) and cesium carbonate (216 g) were stirred in acetonitrile (900 ml) at room temperature under nitrogen for 10 minutes. Ethyl bromoacetate (73 ml) was added and the mixture heated to 40° C. for 3 hours. Further ethyl bromoacetate (2.5 ml) and cesium carbonate (1 g) were added and heating continued for a further hour. The cooled reaction was filtered and the filtrate concentrated to give the title compound as a yellow oil.

Quelle