Reaktion #971064

ord-5f8c4c0dc78545639c106a8c021fe89b

Reaktionsgleichung

Clc1ccc2c(Cl)ccnc2n1
product
Clc1ccc2c(Cl)ccnc2n1
2,5-Dichloro-[1,8]naphthyridine
CC(=O)Nc1ccc(Sc2ccc(C)cc2N)cc1
product
CC(=O)Nc1ccc(Sc2ccc(C)cc2N)cc1
N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide
→
CC(=O)Nc1ccc(Sc2ccc(C)cc2Nc2ccnc3nc(Cl)ccc23)cc1
title compound
Ausbeute 48.0%
CC(=O)Nc1ccc(Sc2ccc(C)cc2Nc2ccnc3nc(Cl)ccc23)cc1
N-{4-[2-(7-Chloro-[1,8]naphthyridin-4-ylamino)-4-methyl-phenylsulfanyl]-phenyl}-acetamide
Ausbeute 48.0%

Edukte

Clc1ccc2c(Cl)ccnc2n1
product
Clc1ccc2c(Cl)ccnc2n1
2,5-Dichloro-[1,8]naphthyridine
CC(=O)Nc1ccc(Sc2ccc(C)cc2N)cc1
product
CC(=O)Nc1ccc(Sc2ccc(C)cc2N)cc1
N-[4-(2-Amino-4-methyl-phenylsulfanyl)-phenyl]-acetamide

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigegiving a crude solid
  2. 2
    Sonstigethat was purified by HPLC with TFA

Vorschrift

The product from Example 21d (200 mg, 1.0 mmol) and the product from Example 22b (215 mg, 1.0 mmol) were reacted following the procedure from Example 7g giving a crude solid that was purified by HPLC with TFA to give the title compound 200 mg, 48%).

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08236950B2uspto-grants-2012_08