Reaktion #9708

Reaktionsgleichung

NaOH

NaHCO3

N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine

methyl trans-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]cyclopentanecarboxylate

dichloromethane

→

trans-2-({4′-[(6-methyl-1,3-benzothiazol-2-yl)amino]-1,1′-biphenyl-4-yl}carbonyl)-cyclopentanecarboxylic acid

Ausbeute 74.0%

Lösungsmittel

EtOH

Toluene

EtOAc

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe resulting solution was degassed
2. 2
   Sonstigeby bubbling a flow of argon for 30 minutes
3. 3
   Filtrationfiltered through a Celite® pad
4. 4
   SonstigeThe solvent was removed by rotary evaporation
5. 5
   EinengenThe reaction mixture was concentrated under reduced pressure
6. 6
   workup.ADDITIONConcentrated HCl was added
7. 7
   Extraktionthe suspension was extracted with EtOAc
8. 8
   WaschenThe combined organic phases were washed with brine
9. 9
   Trocknendried over sodium sulfate
10. 10
    Einengenconcentrated in vacuo
11. 11
    Filtrationthe precipitate was collected by filtration
12. 12
    Waschenwashed with EtOAc, MeOH, and DCM
13. 13
    Sonstigedried in a vacuum oven

Vorschrift

N-(4-iodophenyl)-6-methyl-1,3-benzothiazol-2-amine (0.28 g, 0.78 mmol) and methyl trans-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]cyclopentanecarboxylate (0.25 g, 0.71 mmol) were combined in a dry flask under argon. Toluene (15 mL), EtOH (6 mL), and saturated aqueous NaHCO3 (2 mL) were then added, and the resulting solution was degassed by bubbling a flow of argon for 30 minutes. Then [1,1′-bis(diphenylphosphino)-ferrocene]dichloro-palladium (II), complex with dichloromethane (1:1) (57 mg, 0.07 mmol) was added, and the resulting mixture was heated at 85° C. for 16 h. The reaction mixture was then diluted with EtOAc and filtered through a Celite® pad. The solvent was removed by rotary evaporation and the residue was brought up in MeOH. Then 1 N aqueous NaOH (2.0 mL, 2.0 mmol) was added to the suspension, and the reaction mixture was stirred at 50° C. overnight. The reaction mixture was concentrated under reduced pressure and the residue was suspended in water. Concentrated HCl was added to adjust the acidity to pH 1, and the suspension was extracted with EtOAc. The combined organic phases were washed with brine, dried over sodium sulfate, passed through a pad of silica gel, and concentrated in vacuo. The residue was brought up in EtOAc and the precipitate was collected by filtration, washed with EtOAc, MeOH, and DCM, and dried in a vacuum oven to afford trans-2-({4′-[(6-methyl-1,3-benzothiazol-2-yl)amino]-1,1′-biphenyl-4-yl}carbonyl)-cyclopentanecarboxylic acid (0.24 g, 19%). LC-MC ret. time 3.57; m/z 457.3 (MH+); 1H NMR (400 MHz, DMSO-d6) δ 1.57–1.86 (m, 4H), 2.00 (m, 1H), 2.17 (m, 1H), 2.37 (s, 3H), 3.22 (q, 1H), 4.08 (q, 1H), 7.14 (m, 1H), 7.51 (d, 1H), 7.61 (s, 1H), 7.80 (m, 3H), 7.89 (d, 2H), 8.05 (d, 2H), 10.58 (s, 1H), 12.19 (s, 1H).

Quelle