Reaktion #970653

Reaktionsgleichung

2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde

4′-bromomethylbiphenyl-2-carboxylic acid t-butyl ester

K2CO3

→

intermediate ( 4a )

Ausbeute 89.1%

4′-(2-Butyl-4-chloro-5-formylimidazol-1-ylmethyl)biphenyl-2-carboxylic acid t-butyl ester

Ausbeute 89.1%

Lösungsmittel

DMF

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe reaction was quenched with water
2. 2
   Extraktionextracted with EtOAc
3. 3
   Waschenwashed with saturated aqueous NaCl
4. 4
   Trocknendried over MgSO4
5. 5
   Filtrationfiltered
6. 6
   Einengenconcentrated
7. 7
   SonstigeThe crude mixture was purified by flash chromatography (0-40% EtOAc:hexanes)

Vorschrift

2-Butyl-5-chloro-3H-imidazole-4-carbaldehyde (9.9 g, 53.3 mmol), 4′-bromomethylbiphenyl-2-carboxylic acid t-butyl ester (18.5 g, 53.3 mmol), and K2CO3 (7.4 g, 53.3 mmol) were combined in DMF (200 mL) and stirred at room temperature overnight. The reaction was quenched with water, extracted with EtOAc, washed with saturated aqueous NaCl, dried over MgSO4, filtered and concentrated. The crude mixture was purified by flash chromatography (0-40% EtOAc:hexanes) to yield 21.5 g of intermediate (4a).

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