Reaktion #970448

Reaktionsgleichung

chloroacrylic acid

histidine methyl ester dihydrochloride

triethylamine

→

N(α)-acryloyl-L-histidine methyl ester

Ausbeute 44.8%

Lösungsmittel

methylene chloride

Reaktionsbedingungen

Vorschrift

After chloroacrylic acid (1.6 ml, 20 mmol) was dropped, with ice cooling, into a solution of histidine methyl ester dihydrochloride (6.05 g, 25 mmol) and triethylamine (14 mL, 100 mmol) in methylene chloride (200 mL), the same operation as in the synthesis of N(α)-acryloyl-N(π)-methyl-L-histidine methyl ester was conducted to give N(α)-acryloyl-L-histidine methyl ester (2.0 g, 36%) as an oily product.

Quelle