Reaktion #969906

Reaktionsgleichung

1,4-diazabicyclo[3.2.2]nonane

2-chloro-nitropyridine

dioxane

→

title compound

4-(5-Nitro-pyridin-2-yl)-1,4-diaza-bicyclo[3.2.2]nonane

Lösungsmittel

Water

Reaktionsbedingungen

Aufarbeitung

1. 1
   ExtraktionThe mixture was extracted with dichloromethane (3×50 ml)

Vorschrift

1,4-diazabicyclo[3.2.2]nonane (6.3 g, 50 mmol) was added to a mixture of 2-chloro-nitropyridine (11.9, 75 mmol), and dioxane (250 ml) at 0° C. The reaction mixture was allowed to reach room-temperature. Water (100 ml) was added. The mixture was extracted with dichloromethane (3×50 ml). Chromatography on silica gel with dichloromethane and 10% methanol as solvent gave the title compound as an oil. Yield 8.1 g (65%). Mp. 143-146° C.

Quelle