Reaktion #969905

Reaktionsgleichung

1,4-diazabicyclo[3.2.2]nonane

1-fluoro-4-nitrobenzene

ethylene glycol diethyl ether

→

4-(4-Nitro-phenyl)-1,4-diaza-bicyclo[3.2.2]nonane hydrofluoric acid salt

Lösungsmittel

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.ADDITIONwas added
2. 2
   FiltrationThe mixture was filtered
3. 3
   Sonstigethe product was isolated by filtration

Vorschrift

A mixture of 1,4-diazabicyclo[3.2.2]nonane (20.2 g, 160 mmol), 1-fluoro-4-nitrobenzene (17.5 ml, 163.3 mmol) and ethylene glycol diethyl ether (160 ml) was stirred at 135° C. for 18 hours. The mixture was cooled to room-temperature and diethyl ether (100 ml) was added. The mixture was filtered and the product was isolated by filtration. Yield 24.8 g (58%). Mp. 122-129° C.

Quelle