Reaktion #969894

Reaktionsgleichung

1-(4-chlorophenyl)cyclopropane carboxylic acid

N,O-dimethylhydroxylamine hydrochloride

benzotriazole-1-yloxytrispyrrolidinophosphonium hexafluorophosphate

triethylamine

→

1-(4-chlorophenyl)cyclopropane carboaldehyde

Ausbeute 63.8%

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionextracted with chloroform
2. 2
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
3. 3
   Einengenconcentrated in vacuo
4. 4
   workup.DISSOLUTIONThe obtained residue was dissolved in toluene (30 mL)
5. 5
   workup.ADDITIONadded at −78° C. with a solution of diisobutylaluminum hydride in toluene (1.01 M, 4.35 mL)
6. 6
   workup.STIRRINGthe resultant was stirred at the same temperature for 1 hour
7. 7
   workup.ADDITIONThe reaction solution was added with hydrochloric acid
8. 8
   Extraktionextracted with ethyl acetate
9. 9
   TrocknenThe organic layer was dried over anhydrous sodium sulfate
10. 10
    Einengenconcentrated in vacuo
11. 11
    SonstigeThe obtained residue was purified

Vorschrift

A solution of 1-(4-chlorophenyl)cyclopropane carboxylic acid (784 mg, 3.99 mmol) in dichloromethane (30 mL) was added sequentially at room temperature with N,O-dimethylhydroxylamine hydrochloride (389 mg, 3.99 mmol), benzotriazole-1-yloxytrispyrrolidinophosphonium hexafluorophosphate (2.28 g, 4.39 mmol) and triethylamine (807 mg, 7.97 mmol). The resultant was stirred at the same temperature for 20 min, and extracted with chloroform. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was dissolved in toluene (30 mL), added at −78° C. with a solution of diisobutylaluminum hydride in toluene (1.01 M, 4.35 mL), and the resultant was stirred at the same temperature for 1 hour. The reaction solution was added with hydrochloric acid, and extracted with ethyl acetate. The organic layer was dried over anhydrous sodium sulfate, and concentrated in vacuo. The obtained residue was purified using column chromatography (hexane:ethyl acetate=3:1), and 1-(4-chlorophenyl)cyclopropane carboaldehyde (460 mg, 63.7%) was obtained.

Quelle