Reaktion #969893

Reaktionsgleichung

1-(adamantan-2-yl)-4-(2,5-dihydrobenzo[b]oxepin-9-yl)-3,3-dimethylazetidin-2-one

→

1-(adamantan-2-yl)-3,3-dimethyl-4-(benzo[b]oxepan-9-yl)azetidin-2-one

Ausbeute 76.2%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe reaction solution was filtered
2. 2
   Einengenconcentrated in vacuo

Vorschrift

A solution of 1-(adamantan-2-yl)-4-(2,5-dihydrobenzo[b]oxepin-9-yl)-3,3-dimethylazetidin-2-one (21.1 mg, 0.0560 mmol) in methanol (2 mL) was added with palladium carbon ethylenediamine complex (catalyst amount), and the resultant was stirred at room temperature for 6 hours under a hydrogen atmosphere. The reaction solution was filtered using celite, concentrated in vacuo, and 1-(adamantan-2-yl)-3,3-dimethyl-4-(benzo[b]oxepan-9-yl)azetidin-2-one (16.2 mg, 76.2%) was obtained as a colorless oil.

Quelle