Reaktion #969877

Reaktionsgleichung

6-aminoquinoline

1-hydroxibenzotriazol

Z-Val-Pro-OH

N,N′-diisopropylcarbodiimide

→

Z-Val-Pro 6-aminoquinoline

Lösungsmittel

dichloromethane

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigewas continued until the complete disappearance of the starting material (overnight)
2. 2
   SonstigeThen, the solvent was evaporated
3. 3
   workup.DISSOLUTIONthe residue was dissolved in ethyl acetate
4. 4
   Waschenwashed with citric acid (10%), NaHCO3 (10%) and brine
5. 5
   TrocknenThe organic layer was dried (Na2SO4)
6. 6
   Sonstigeevaporated
7. 7
   Sonstigeleaving a residue that
8. 8
   Sonstigewas purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4)
9. 9
   Sonstigeto yield H (20
10. 10
    Sonstigeyield

Vorschrift

A solution of Z-Val-Pro-OH (217.4 mg, 0.62 mmol) in dichloromethane (1.5 mL), was successively treated at room temperature. with 1-hydroxibenzotriazol (84.3 mg, 0.62 mmol), N,N′-diisopropylcarbodiimide (97.2 μL, 0.62 mmol) and 6-aminoquinoline (75 mg, 0.52 mmol). The stirring was continued until the complete disappearance of the starting material (overnight). Then, the solvent was evaporated, the residue was dissolved in ethyl acetate and washed with citric acid (10%), NaHCO3 (10%) and brine. The organic layer was dried (Na2SO4) and evaporated leaving a residue that was purified by CCTLC on the chromatotron with hexane/ethyl acetate (1:4) to yield H (20 yield

Quelle