Reaktion #968582

Reaktionsgleichung

4-(2-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester

HCl

→

4-(2-fluoro-benzenesulfonyl)-piperazine hydrochloride salt

Lösungsmittel

methanol

dichloromethane

diethyl ether

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturcooled in ice bath
2. 2
   Filtrationthe resulted precipitate was filtered
3. 3
   Waschenwashed with ether

Vorschrift

4-(2-Fluoro-benzenesulfonyl)-piperazine-1-carboxylic acid tert-butyl ester (891 mg) was dissolved in methanol (10 ml) and dichloromethane (5 ml), 2M HCl in diethyl ether (12.9 ml) was added and the reaction mixture was stirred at room temperature overnight, then cooled in ice bath, the resulted precipitate was filtered, washed with ether to yield 4-(2-fluoro-benzenesulfonyl)-piperazine hydrochloride salt (600 mg).

Quelle