Reaktion #967692

Reaktionsgleichung

4-fluoro-indoline

acetic anhydride

→

1-(4-fluoro-indolin-1-yl)ethanone

Ausbeute 77.0%

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigeThe resulting mixture was partitioned between ethyl acetate (100 mL) and water (100 mL)
2. 2
   SonstigeThe organic layer was separated
3. 3
   Extraktionthe aqueous layer was extracted with ethyl acetate (5×30 mL)
4. 4
   WaschenThe combined organic layers were washed with water (3×20 mL), sodium bicarbonate solution (3×20 mL), brine (3×20 mL)
5. 5
   Trocknendried over anhydrous sodium sulphate
6. 6
   Einengenconcentrated in vacuo

Vorschrift

A mixture of 4-fluoro-indoline (1 g, 7.30 mmol) and acetic anhydride (10 mL) was stirred at ambient temperature for 1 h. The resulting mixture was partitioned between ethyl acetate (100 mL) and water (100 mL). The organic layer was separated and the aqueous layer was extracted with ethyl acetate (5×30 mL). The combined organic layers were washed with water (3×20 mL), sodium bicarbonate solution (3×20 mL), brine (3×20 mL), dried over anhydrous sodium sulphate and concentrated in vacuo to afford 1-(4-fluoro-indolin-1-yl)ethanone (1 g, 77%) as a white solid.

Quelle