Reaktion #9669

Reaktionsgleichung

Sulfuryl chloride

5-fluoro-1,3-benzothiazole-2-thiol

→

2-Chloro-5-fluoro-1,3-benzothiazole

Reaktionsbedingungen

Aufarbeitung

1. 1
   Temperaturheated at 60° C. for 30 minutes
2. 2
   TemperaturThe resulting solution was cooled to rt
3. 3
   workup.ADDITIONpoured onto ice
4. 4
   FiltrationThe title compound was collected by filtration
5. 5
   Waschenwashed with water
6. 6
   Sonstigedried under vacuum
7. 7
   SonstigeThe solid obtained
8. 8
   Sonstigewas used without further purification

Vorschrift

Sulfuryl chloride (50 μL, 0.65 mmol) was added neat to 5-fluoro-1,3-benzothiazole-2-thiol (100 mg, 0.54 mmol). The mixture was stirred at ambient temperature for 1 h, then heated at 60° C. for 30 minutes. The resulting solution was cooled to rt, and poured onto ice. The title compound was collected by filtration, washed with water, and dried under vacuum. The solid obtained was used without further purification; LC-MS m/z 188.1 (MH+), ret. time 3.27 min.

Quelle