Reaktion #966415

Reaktionsgleichung

tert.-butyl-(3R,4S,5S)-4-[{N-[(benzyloxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

intermediate 1

tert.-butyl-(3R,4S,5S)-4-[{N-[(benzyloxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate

→

title compound

tert.-butyl-(3R,4S,5S)-3-methoxy-5-methyl-4-[methyl(L-valyl)amino]heptanoate

Lösungsmittel

Methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   FiltrationThe catalyst was then filtered off
2. 2
   Sonstigethe solving agents was removed in a vacuum

Vorschrift

500 mg (1 mmol) tert.-butyl-(3R,4S,5S)-4-[{N-[(benzyloxy)carbonyl]-L-valyl}(methyl)amino]-3-methoxy-5-methylheptanoate (intermediate 1) were dissolved in 50 ml Methanol and, after adding 100 mg 10% Palladium on activated carbon, was hydrated at RT for 1 h under atmospheric pressure. The catalyst was then filtered off and the solving agents was removed in a vacuum. 370 mg (quant.) of the title compound were obtained an almost colorless oil.

Quelle