Reaktion #965832

Reaktionsgleichung

[4-fluoro-2-[(E)-2-(4-fluorophenyl)ethenyl]phenyl]methanol

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title compound

Ausbeute 37.0%

[4-fluoro-2-[2-(4-fluorophenyl)ethyl]phenyl]methanol

Ausbeute 37.0%

Lösungsmittel

methanol

Reaktionsbedingungen

Aufarbeitung

1. 1
   Sonstigethe mixture was then purged with hydrogen
2. 2
   FiltrationIt was then filtered
3. 3
   Einengenfiltrate concentrated
4. 4
   Sonstigeto give a residue which
5. 5
   Sonstigewas purified by flash column chromatograph

Vorschrift

Charged [4-fluoro-2-[(E)-2-(4-fluorophenyl)ethenyl]phenyl]methanol (568 mg, 2.31 mmol, EXAMPLE 119, part A), Pd/C (65 mg) and methanol (6 mL) to a flask, the mixture was then purged with hydrogen, stirred at room temperature overnight. It was then filtered, filtrate concentrated to give a residue which was purified by flash column chromatograph to give 214 mg of the title compound (37%). 1H NMR (400 MHz, CDCl3): δ 1.42 (1H, t, J=5.2 Hz), 2.83-2.98 (4H, m), 4.59 (2H, d, J=5.6 Hz), 6.88-6.98 (4H, m), 7.08-7.11 (2H, m), 7.29-7.33 (1H, m).

Quelle