Reaktion #965196

Reaktionsgleichung

pyridin-3-ylamine

Et2O

pivaloyl chloride

Et3N

→

title compound

2,2-Dimethyl-N-pyridin-3-yl-propionamide

Lösungsmittel

THF

THF

Reaktionsbedingungen

Aufarbeitung

1. 1
   workup.WAITleft
2. 2
   SonstigeAfter the completion of reaction
3. 3
   Filtrationthe reaction mixture was filtered
4. 4
   Sonstigethe filtrate was evaporated in vacuo
5. 5
   FiltrationThe crude filter cake
6. 6
   Waschenwas washed with n-hexane

Vorschrift

To a solution of pyridin-3-ylamine (20 g, 212.49 mmol, CAS RN 462-08-8) in a mixture of THF:Et2O (175 mL; 2.5:1 v/v) was added slowly a solution of pivaloyl chloride (26 mL, 212.5 mmol, CAS RN 3282-30-2) in THF (50 mL) and Et3N (44 mL, 318.7 mmol) at 0° C. and left stirring at that temperature for 1 h. After the completion of reaction, the reaction mixture was filtered, and the filtrate was evaporated in vacuo. The crude filter cake was washed with n-hexane to yield the title compound. Colorless crystalline solid (32 g, 85%). MS (ESI): m/z=179.4 [M+H]+.

Quelle