Reaktion #964102

Reaktionsgleichung

6-Chloro-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

3-methylpyrazole-4-boronic acid pinacol ester

→

120

N-(3-methoxyphenyl)-1-methyl-6-(3-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Reaktionsbedingungen

Aufarbeitung

1. 1
   SonstigePurification on silica

Vorschrift

6-Chloro-N-(3-methoxyphenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine 6 was reacted with 3-methylpyrazole-4-boronic acid pinacol ester using General Procedure A. Purification on silica yielded 120. NMR: (CDCl3): 2.80 (s, 3H, CH3), 3.87 (s, 3H, CH3), 4.06 (s, 3H, CH3), 6.86 (dd, H, ArH, J=1.7, 8.29), 7.14 (dd, H, ArH, J=1.2, 7.89), 7.25 (s, H, ArH), 7.36 (t, H, ArH, J=8.11), 7.44 (s, H, ArH), 8.32 (s, H, ArH). MS: (ESI+) MH+=336.24

Quelle