Reaktion #962165

ord-d7275e3393a64a5f98fee4f3d9c9ffeb

Reaktionsgleichung

CC(C)(C)OC(=O)N1CCCC(c2nc(-c3ccc(F)cc3)cs2)C1
tert-butyl 3-(4-(4-fluorophenyl)thiazol-2-yl)piperidine-1-carboxylate
O=C([O-])C(F)(F)F
trifluoroacetate
→
Fc1ccc(-c2csc(C3CCCNC3)n2)cc1.O=C(O)C(F)(F)F
4-(4-Fluorophenyl)-2-(piperidin-3-yl)thiazole TFA Salt

Edukte

CC(C)(C)OC(=O)N1CCCC(c2nc(-c3ccc(F)cc3)cs2)C1
tert-butyl 3-(4-(4-fluorophenyl)thiazol-2-yl)piperidine-1-carboxylate
O=C([O-])C(F)(F)F
trifluoroacetate

Reagenzien

Keine

Reaktionsbedingungen

Detaillierte Bedingungen
See reaction.notes.procedure_details.

Aufarbeitung

  1. 1
    Sonstigewas carried through without further purification

Vorschrift

This compound was synthesized from tert-butyl 3-(4-(4-fluorophenyl)thiazol-2-yl)piperidine-1-carboxylate as described for example 46 step 4 (80 mg, crude) as a trifluoroacetate salt and it was carried through without further purification. MS (ESI) m/z: Calculated for C14H15FN2S: 262.09. found: 263.0 (M+H)+

Quelle

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08981084B2uspto-grants-2015_03