Reaktion #962131

Reaktionsgleichung

6-bromonicotinonitrile

tert-butyl 4-iodopiperidine-1-carboxylate

H-Boc

→

tert-Butyl 4-(5-cyanopyridin-2-yl)piperidine-1-carboxylate

Ausbeute 27.0%

Reaktionsbedingungen

Vorschrift

This compound was synthesized from 6-bromonicotinonitrile and tert-butyl 4-iodopiperidine-1-carboxylate as described for example 49 step 1 (150 mg, yield 27%). 1H NMR (400 MHz, CDCl3) δ 8.82 (d, J=2.0 Hz, 1H), 7.91 (dd, J=8.2 Hz, 2.1 Hz, 1H), 7.30 (d, J=8.0 Hz, 1H), 4.28 (m, 2H), 2.97-2.81 (m, 3H), 1.91 (m, 2H), 1.78-1.67 (m, 2H), 1.48 (s, 9H). MS (ESI) m/z: Calculated for C16H21N3O2: 287.16. found: 188.2 (M+H-Boc)+

Quelle