Reaktion #962

Reaktionsgleichung

(3RS)-1-benzyl-3-chloromethyl pyrrolidine

sodium cyanide

Water

→

product

Ausbeute 92.0%

(3RS)-1-benzyl-3-cyanomethyl pyrrolidine

Ausbeute 92.0%

Lösungsmittel

dimethyl sulfoxide

Reaktionsbedingungen

Aufarbeitung

1. 1
   Extraktionthe mixture was extracted three times with ethyl acetate
2. 2
   WaschenThe combined organic layer was washed with brine
3. 3
   Trocknendried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Sonstigeevaporated

Vorschrift

16.8 g (0.08 mole) (3RS)-1-benzyl-3-chloromethyl pyrrolidine and 5.88 g (0.12 mole) of sodium cyanide was dissolved in 250 ml dimethyl sulfoxide. The mixture was stirred at 60° C. for two days and at room temperature for one week. Water was added and the mixture was extracted three times with ethyl acetate. The combined organic layer was washed with brine, dried (Na2SO4), filtered and evaporated to yield 14.7 g (92%) of the product.

Quelle